Detalhe da pesquisa
1.
Structure-based discovery of opioid analgesics with reduced side effects.
Nature
; 537(7619): 185-190, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27533032
2.
Automated design of ligands to polypharmacological profiles.
Nature
; 492(7428): 215-20, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23235874
3.
A pharmacological organization of G protein-coupled receptors.
Nat Methods
; 10(2): 140-6, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291723
4.
In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.
PLoS Biol
; 11(11): e1001712, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24260022
5.
HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.
Bioinformatics
; 30(4): 588-9, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24376084
6.
Discovery of ß-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
Proc Natl Acad Sci U S A
; 108(45): 18488-93, 2011 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22025698
7.
Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism.
Neuropharmacology
; 144: 301-311, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30399367
8.
Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and ß-arrestin 2 in inflammatory macrophages.
Mol Immunol
; 106: 12-21, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576947
9.
Author Correction: PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.
Nat Struct Mol Biol
; 31(3): 578, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486111
10.
Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets.
J Med Chem
; 61(15): 6830-6845, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990431
11.
Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.
SLAS Discov
; 23(10): 1083-1091, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29958052
12.
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor.
Sci Rep
; 6: 27390, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27278076
13.
G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.
PLoS One
; 11(4): e0152856, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27049755
14.
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.
Nat Struct Mol Biol
; 22(5): 362-9, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25895059
15.
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.
Chem Biol
; 22(6): 764-75, 2015 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26091169
16.
The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.
Structure
; 22(12): 1744-1753, 2014 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456411
17.
Colloidal aggregation causes inhibition of G protein-coupled receptors.
J Med Chem
; 56(6): 2406-14, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23437772
18.
Conformation guides molecular efficacy in docking screens of activated ß-2 adrenergic G protein coupled receptor.
ACS Chem Biol
; 8(5): 1018-26, 2013 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23485065
19.
Discovery of ß2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
ACS Med Chem Lett
; 4(10): 1005-1010, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24454993
20.
Structure-functional selectivity relationship studies of ß-arrestin-biased dopamine D2 receptor agonists.
J Med Chem
; 55(16): 7141-53, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22845053